Green Bay Packers vs. Washington Commanders
Thursday, 8:15 p.m. ET
FanDuel odds: Packers -3.5, Total 48.5
Just when the Commanders thought they were rid of Micah Parsons, the pass-rushing menace went from the Dallas Cowboys to the Packers 14 days before the Week 2 matchup. Parsons is all too familiar of a nemesis for Washington. He has more sacks — 10.5 — against Washington than any other opponent and pulled down QB Jayden Daniels 4.5 times in two meetings last season. Daniels has a few new friends on his side this season. The Commanders traded for Houston Texans LT Laremy Tunsil and San Francisco 49ers WR Deebo Samuel, who had a 19-yard TD run and led the team with seven receptions for 77 yards in his debut. The Packers pounded the Detroit Lions last week and QB Jordan Love has eight touchdowns (one rushing) in four career Thursday games. RB Josh Jacobs has a rushing touchdown in 10 consecutive games.
Cincinnati Bengals vs. Jacksonville Jaguars
Sunday, 1 p.m. ET
FanDuel odds: Bengals -3.5, Total 49.5
Notoriously slow starters since Zac Taylor and Joe Burrow arrived, the Bengals were last 2-0 to open a season in 2018. Burrow played in preseason games with the idea of sparking the offense in September, then threw for 113 yards in Week 1. Jacksonville attempts to keep the Bengals down and get to 2-0 out of the gate – also for the first time since 2018 – but Burrow averaged three TDs per game in his last eight home starts. New Jaguars head coach Liam Coen deployed No. 2 pick Travis Hunter at wide receiver and he led the team with six receptions. Hunter could get more time at cornerback on Sunday to assist in the mission of covering Ja’Marr Chase and Tee Higgins. The Bengals WR duo combined for 14 TD catches at home last season.
Dallas Cowboys vs. New York Giants
Sunday, 1 p.m. ET
FanDuel odds: Cowboys -5.5, Total 44.5
Without Parsons, the Cowboys did almost enough to upset the Philadelphia Eagles in a wild opening night game that included a fastbreak pace in the first half and a long weather delay. Dak Prescott was dialed in from the jump and could’ve approached outlandish numbers if not for three critical drops by WR CeeDee Lamb. After spending time on hand-eye coordination this week, Lamb can get back to the business of harassing the Giants as he goes for his fourth 100-yard game in six career meetings. Prescott has won 13 consecutive games against the Giants with 30 TDs (29 TD passes) and a 102.4 rating in 15 career games against New York. There are questions around the Giants QB situation with rookie first-round pick Jaxson Dart waiting in the wings. Russell Wilson had an interception overturned by penalty and never found the end zone in his first start with the Giants last week, a 21-6 defeat at Washington. There was little room to run and LT Andrew Thomas (foot) missed the game.
Detroit Lions vs. Chicago Bears
Sunday, 1 p.m. ET
FanDuel odds: Lions -5.5, Total 46.5
A little game of lost and found is in order for the Lions and Bears as former offensive coordinator Ben Johnson makes his return to Detroit. Without him at Green Bay last week, the offense was erratic and blocking left a lot of be desired. New coordinator John Morton gets back to the drawing board to tackle a Bears defense embarrassed on Monday night by first-time starter J.J. McCarthy and the Vikings. Minnesota rallied from a 17-6 deficit to shock Johnson and the Bears, 27-24. A focus on ground-and-pound should be expected from Detroit, which had only one touchdown and a single pass play of 20-plus yards in Week 1. The Lions’ dynamic rushing duo of Jahmyr Gibbs and David Montgomery was limited to 44 yards on 20 carries. The Lions reached the 30-point mark in 10 regular-season games while averaging 409.5 yards per game. Chicago changed out three starting offensive linemen in the offseason, but QB Caleb Williams never appeared fully comfortable in the pocket last week. Williams passed for 590 yards (295 per game) and five TDs with zero interceptions and a 102.8 rating in two starts against the Lions as a rookie.
Tennessee Titans vs. Los Angeles Rams
Sunday, 1 p.m. ET
FanDuel odds: Rams -5.5, Total 41.5
Puka Nacua’s fifth career 10-catch game was a highlight for the Rams and Matthew Stafford in Week 1, when the QB cleared 60,000 career passing yards in his 223rd game. It was just the first game of Cam Ward’s career at Denver, but the Titans were well within striking distance most of the game. Ward had zero turnovers but faced constant pressure, passing for 112 yards and completing 12 of 28 attempts. The Rams’ front seven is a beast to block because of the number of penetrating threats an offensive line must account for, which makes it a bad time for Titans LT JC Latham (hip) to miss time. The Titans are capable of getting to quarterbacks, too. DT Jeffery Simmons had three sacks the last time he faced the Rams and had a sack and forced fumble in Week 1.
Miami Dolphins vs. New England Patriots
Sunday, 1 p.m. ET
FanDuel odds: Dolphins -1.5, Total 43.5
Patriots QB Drake Maye was a teenager the last time the Patriots won in Miami (2019) and head coach Mike Vrabel cautioned New England not to view the Dolphins as easy prey despite a dud at Indianapolis last week. The Patriots played well enough to beat the Raiders last week but came up short in the red zone with field goals on two of three possessions inside the Las Vegas 20. Miami didn’t score until the fourth quarter of a 33-8 loss and issues on the offensive line and timing between QB Tua Tagovailoa and his receivers were glaring. Tagovailoa had a performance coach Mike McDaniel described as “less than expected” with three turnovers. Vrabel said the combination of South Florida weather and the circling critique of Miami’s Week 1 output leave the Patriots in a sticky spot. Tagovailoa has never lost to the Patriots (7-0) and posted an 11-0 TD-to-INT ratio in his final five home starts last season.
New Orleans Saints vs. San Francisco 49ers
Sunday, 1 p.m. ET
FanDuel odds: 49ers -4.5, Total 41.5
Neither team — nor fan base — likely expected to see Mac Jones vs. Spencer Rattler when the 2025 schedule was released, but here we are in the Superdome. It will be Jones’ 50th start but first for the 49ers, who could be without Brock Purdy (toe) for the rest of the month. Rattler won the QB job for the Saints and makes his fifth career home start in a matchup of teams trying to generate consistent offense. The 49ers (17-13 winners at Seattle) escaped with a win in the opener but Christian McCaffrey had 31 touches in his return from an injury-riddled 2024 season. Rattler can lean on RB Alvin Kamara to move the chains. Kamara and McCaffrey are two of four active players averaging at least 100 yards from scrimmage per game (Colts RB Jonathan Taylor, Eagles RB Saquon Barkley).
New York Jets vs. Buffalo Bills
Sunday, 1 p.m. ET
FanDuel odds: Bills -6.5, Total 46.5
The Jets came out of a Week 1 loss to the Steelers with plenty of positives – 394 total yards, a franchise-best in an opener in the past 11 seasons – in Justin Fields’ first start. Perhaps the biggest of the superlatives from coach Aaron Glenn was the play of a dominant offensive line, which feeds into the game plan for Week 2. RB Breece Hall averaged 158 yards per game in two previous home matchups with the Bills, and keep-away is a reasonable game plan. Buffalo had a league-best 41 points and 497 total yards, and the Bills needed every last one of them because the Ravens rang up multiple big plays with 40 points and 432 yards from scrimmage. QB Josh Allen and WR Keon Coleman connected better than ever (8-112-1), particularly in the fourth quarter.
Pittsburgh Steelers vs. Seattle Seahawks
Sunday, 1 p.m. ET.
FanDuel odds: Steelers -2.5, Total 39.5
Quarterbacks unafraid to start over are the focal point with Aaron Rodgers on the verge of more history if the Steelers can keep him upright. LT Broderick Jones allowed three of the four sacks Pittsburgh gave up last week in a 34-32 win over the Jets. After four TD tosses in that game, Rodgers is one behind Green Bay predecessor Brett Favre (508) on the NFL’s all-time career TD pass list. Rodgers also could clear Philip Rivers (63,440) for the sixth-most regular-season passing yards in NFL history. He enters Sunday with 63,196. Seattle lost its home opener when new QB Sam Darnold dropped the ball in a collision with his offensive line that sealed San Francisco’s 17-13 win. He was laser-locked on new No. 1 wide receiver Jaxon Smith-Njigba, Darnold’s target on 59.1 percent of his passes. The Seahawks could be without playmaking safety Devon Witherspoon, who didn’t practice Wednesday, in a matchup with their former lead receiver, DK Metcalf.
Baltimore Ravens vs. Cleveland Browns
Sunday, 1 p.m. ET
FanDuel odds: Ravens -10.5, Total 44.5
Joe Flacco won a Super Bowl with the Ravens and no doubt Baltimore didn’t expect to see him back at age 40 as a starter in the division. Flacco, the franchise leader in passing yards (38,245) and TD passes (212), is backed by a dominant defense that held the Bengals under 10 yards of offense in the second half last week. But Cleveland still lost, and now the test is Lamar Jackson, Derrick Henry and Zay Flowers, who put up 40 points at Buffalo – and still lost. Jackson replaced Flacco as Baltimore’s starter and has dominated the Browns and excelled at home (21 TDs, three INTs in nine home starts last season).
